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Viser: Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders - Alzheimer's Disease
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Vital Source e-bog
Adeboye Adejare
(2016)
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
Alzheimer's Disease
Adeboye Adejare
(2016)
Sprog: Engelsk
Detaljer om varen
- Vital Source searchable e-book (Reflowable pages)
- Udgiver: Elsevier Science (September 2016)
- ISBN: 9780128028117
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success.
The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders.
- Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders
- Examines different classes of compounds currently being used in discovery and development stages
- Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions
- Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource
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Detaljer om varen
- Hardback: 316 sider
- Udgiver: Elsevier Science & Technology (Oktober 2016)
- ISBN: 9780128028100
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer's Disease and illustrating the paradigm necessary to ensure future research and treatment success.
The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer's Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer's Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders.
- Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders
- Examines different classes of compounds currently being used in discovery and development stages
- Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions
- Distills the most significant information across multiple areas of Alzheimer's disease research to provide a single, comprehensive, and balanced resource
2. Alzheimer's disease diagnosis
3. National plan and resources to address Alzheimer's disease
4. Current Medications for Treatment of Alzheimer's Disease: Acetylcholine esterase inhibitors and NMDA receptor antagonist
5. Physicochemical properties for potential AD drugs
6. Receptor approaches
7. Amyloid hypothesis
8. Tau proteins
9. Cholesterol and fat metabolism
10. Energy Metabolism
11. Simple in vivo models of Neurodegeneration (C. Elegans, fruitfly, and similar models)
12. Rodent Models
13. Clinical Trials
14. Non-pharmacologic Treatment Approaches