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Molecular Diagnostics Vital Source e-bog
George P. Patrinos
(2016)
Molecular Diagnostics
George P. Patrinos, Wilhelm Ansorge og Phillip B. Danielson
(2016)
Sprog: Engelsk
Detaljer om varen
- 3. Udgave
- Vital Source searchable e-book (Reflowable pages)
- Udgiver: Elsevier Science (Oktober 2016)
- ISBN: 9780128029886
Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter.
Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies.
All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor.
The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management.
- Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories
- Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression
- Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field
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Detaljer om varen
- 3. Udgave
- Hardback: 520 sider
- Udgiver: Elsevier Science & Technology (November 2016)
- Forfattere: George P. Patrinos, Wilhelm Ansorge og Phillip B. Danielson
- ISBN: 9780128029718
Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter.
Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies.
All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor.
The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management.
- Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories
- Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression
- Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field
2. Describing DNA Variants (Mutation Nomenclature)
3. Low- and Medium-Throughput Variant Detection Methods: A Historical Perspective
4. Quantitative Polymerase Chain Reaction
5. Integrated Polymerase Chain Reaction Technologies (Sample-to-Answer Technologies)
6. High-Resolution Melting Curve Analysis for Molecular Diagnostics
7. Molecular Techniques for DNA Methylation Studies
8. Perspectives for Future DNA Sequencing Techniques and Applications
9. Advanced Personal Genome Sequencing as the Ultimate Diagnostic Test
10. Application of Padlock and Selector Probes in Molecular Medicine
11. Advances in Microfluidics and Lab-on-a-Chip Technologies
12. Protein Diagnostics by Proximity Ligation: Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses
13. Application of Proteomics to Medical Diagnostics
14. Molecular Cytogenetics in Molecular Diagnostics
15. Cytogenomics of Solid Tumors by Next-Generation Sequencing: A Clinical Perspective
16. Pharmacogenomics in Clinical Care and Drug Discovery
17. Nutrigenomics: Integrating Genomic Approaches Into Nutrition Research 18. DNA Microarrays and Genetic Testing
19. Bioinformatics Tools for Data Analysis
20. Genomic Databases: Emerging Tools for Molecular Diagnostics
21. Molecular Diagnostic Applications in Forensic Science
22. New Perspectives in Mass Disaster Victim Identification Assisted by DNA Typing and Forensic Genomics
23. Preimplantation Genetic Diagnosis
24. Noninvasive Cell-Free DNA Prenatal Testing for Fetal Aneuploidy in Maternal Blood
25. Genetic Testing and Psychology
26. Genomic Medicine in Developing Countries and Resource-Limited Environments
27. Public Understanding of Genetic Testing and Obstacles to Genetics Literacy
28. Safety and the Biorepository
29. Quality Assurance in Genetic Laboratories