SØG - mellem flere end 8 millioner bøger:
Viser: Molecular Pharmacology - From DNA to Drug Discovery
Søgbar e-bog
Molecular Pharmacology: From DNA to Drug Discovery Vital Source e-bog
John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
(2012)
John Wiley & Sons
642,00 kr.
Leveres umiddelbart efter køb
Søgbar e-bog
Molecular Pharmacology: From DNA to Drug Discovery Vital Source e-bog
John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
(2012)
John Wiley & Sons
642,00 kr.
Leveres umiddelbart efter køb
Molecular Pharmacology: From DNA to Drug Discovery Vital Source e-bog
John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
(2012)
John Wiley & Sons
259,00 kr.
Leveres umiddelbart efter køb
Molecular Pharmacology
From DNA to Drug Discovery
John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
(2012)
Sprog: Engelsk
John Wiley & Sons, Limited
710,00 kr.
ikke på lager, Bestil nu og få den leveret
om ca. 10 hverdage
om ca. 10 hverdage
Detaljer om varen
- 1. Udgave
- Vital Source searchable e-book (Fixed pages)
- Udgiver: John Wiley & Sons (November 2012)
- Forfattere: John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
- ISBN: 9781118451977
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.
Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell.
- Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.
- Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.
- Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.
- Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Licens varighed:
Bookshelf online: 5 år fra købsdato.
Bookshelf appen: ubegrænset dage fra købsdato.
Udgiveren oplyser at følgende begrænsninger er gældende for dette produkt:
Print: 10 sider kan printes ad gangen
Copy: højest 2 sider i alt kan kopieres (copy/paste)
Bookshelf online: 5 år fra købsdato.
Bookshelf appen: ubegrænset dage fra købsdato.
Udgiveren oplyser at følgende begrænsninger er gældende for dette produkt:
Print: 10 sider kan printes ad gangen
Copy: højest 2 sider i alt kan kopieres (copy/paste)
Detaljer om varen
- 1. Udgave
- Vital Source searchable e-book (Reflowable pages)
- Udgiver: John Wiley & Sons (November 2012)
- Forfattere: John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
- ISBN: 9781118451953
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Licens varighed:
Bookshelf online: 5 år fra købsdato.
Bookshelf appen: ubegrænset dage fra købsdato.
Udgiveren oplyser at følgende begrænsninger er gældende for dette produkt:
Print: 10 sider kan printes ad gangen
Copy: højest 2 sider i alt kan kopieres (copy/paste)
Bookshelf online: 5 år fra købsdato.
Bookshelf appen: ubegrænset dage fra købsdato.
Udgiveren oplyser at følgende begrænsninger er gældende for dette produkt:
Print: 10 sider kan printes ad gangen
Copy: højest 2 sider i alt kan kopieres (copy/paste)
Detaljer om varen
- 1. Udgave
- Vital Source 120 day rentals (dynamic pages)
- Udgiver: John Wiley & Sons (November 2012)
- Forfattere: John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
- ISBN: 9781118451953R120
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book. A companion website with additional resources is available at www.wiley.com/go/dickenson/dnamolecular
Licens varighed:
Bookshelf online: 120 dage fra købsdato.
Bookshelf appen: 120 dage fra købsdato.
Udgiveren oplyser at følgende begrænsninger er gældende for dette produkt:
Print: 10 sider kan printes ad gangen
Copy: højest 2 sider i alt kan kopieres (copy/paste)
Bookshelf online: 120 dage fra købsdato.
Bookshelf appen: 120 dage fra købsdato.
Udgiveren oplyser at følgende begrænsninger er gældende for dette produkt:
Print: 10 sider kan printes ad gangen
Copy: højest 2 sider i alt kan kopieres (copy/paste)
Detaljer om varen
- Paperback: 432 sider
- Udgiver: John Wiley & Sons, Limited (December 2012)
- Forfattere: John Dickenson, Fiona Freeman, Chris Lloyd Mills, Christian Thode og Shiva Sivasubramaniam
- ISBN: 9780470684436
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of 'trial and error' drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.
Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell.
- Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.
- Cutting Edge - highlights advances in pharmacogenomics and explores how an individual's genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.
- Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.
- Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
Preface ix Abbreviations x 1 Introduction to Drug Targets and Molecular Pharmacology 1
1.1 Introduction to molecular pharmacology 1
1.2 Scope of this textbook 2
1.3 The nature of drug targets 3
1.4 Future drug targets 7
1.5 Molecular pharmacology and drug discovery 11 References 12 2 Molecular Cloning of Drug Targets 13
2.1 Introduction to molecular cloning - from DNA to drug discovery 13
2.2 ''Traditional'' pharmacology 14
2.3 The relevance of recombinant DNA technology to pharmacology/drug discovery 14
2.4 The ''cloning'' of drug targets 15
2.5 What information can DNA cloning provide? 20
2.6 Comparing the pharmacologic profile of the ''cloned'' and the ''native'' drug target 23
2.7 Reverse pharmacology illustrated on orphan GPCRs 24
2.8 Summary 27 References 27 3 G Protein-coupled Receptors 31
3.1 Introduction to G protein-coupled receptors 31
3.2 Heterotrimeric G-proteins 36
3.3 Signal transduction pathways 40
3.4 Desensitisation and down-regulation of GPCR signalling 44
3.5 Constitutive GPCR activity 45
3.6 Promiscuous G-protein coupling 47
3.7 Agonist-directed signalling 48
3.8 Allosteric modulators of GPCR function 49
3.9 Pharmacological chaperones for GPCRs 50
3.10 GPCR dimerisation 51
3.11 GPCR splice variants 63
3.12 Summary 67 References 67 Useful Web sites 70 4 Ion Channels 71
4.1 Introduction 71
4.2 Voltage-gated ion channels 73
4.3 Other types of voltage-gated ion channels 89
4.4 Ligand-gated ion channels 109
4.5 Summary 125 References 125 5 Transporter Proteins 129
5.1 Introduction 129
5.2 Classification 129
5.3 Structural analysis of transporters 132
5.4 Transporter families of pharmacological interest 133
5.5 Transporters and cellular homeostasis 167
5.6 Summary 169 References 169 6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease 175
6.1 Introduction 175
6.2 Cystic fibrosis transmembrane conductance regulator 179
6.3 Mutations in CFTR 183
6.4 Why is cystic fibrosis so common? 184
6.5 Animal models of Cystic fibrosis 186
6.6 Pharmacotherapy 186
6.7 Gene therapy 191
6.8 Conclusion 195 References 196 7 Pharmacogenomics 201
7.1 Types of genetic variation in the human genome 201
7.2 Thiopurine S-methyltransferase and K+ channel polymorphisms 202
7.3 Polymorphisms affecting drug metabolism 204
7.4 Methods for detecting genetic polymorphisms 209
7.5 Genetic variation in drug transporters 211
7.6 Genetic variation in G protein coupled receptors 215
7.7 Summary 225 References 225 Useful Web sites 226 8 Transcription Factors and Gene Expression 227
8.1 Control of gene expression 227
8.2 Transcription factors 229
8.3 CREB 233
8.4 Nuclear receptors 238
8.5 Peroxisome proliferator-activated receptors 240
8.6 Growth factors 247
8.7 Alternative splicing 247
8.8 RNA editing 251
8.9 The importance of non-coding RNAs in gene expression 257
8.10 Summary 270 References 271 9 Cellular Calcium 277
9.1 Introduction 277
9.2 Measurement of calcium 278
9.3 The exocrine pancreas 289
9.4 Calcium signalling in pancreatic acinar cells 292
9.5 Nuclear calcium signalling 303
9.6 Conclusions 310 References 311 10 Genetic Engineering of Mice 315
10.1 Introduction to genetic engineering 315
10.2 Genomics and the accumulation of sequence data 315
10.3 The mouse as a model organism 318
10.4 Techniques for genetic engineering 319
10.5 Examples of genetically-engineered mice 332
10.6 Summary 334 References 334 11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts 339
11.1 Introduction to cell signalling complexes 339
11.2 Introduction to GPCR interacting proteins 340
11.3 Methods used to identify GPCR interacting proteins 340
11.4 Functional roles of GPCR interacting proteins 345
11.5 GPCR signalling complexes 348
11.6 GPCR and ion channel complexes 355
11.7 Ion channel signalling complexes 356
11.8 Development of pharmaceuticals that target GPCR interacting proteins 356
11.9 Development of pharmaceuticals that target protein-protein interactions 356
11.10 Lipid rafts 357
11.11 Receptor-mediated endocytosis 361
11.12 Summary 364 References 364 12 Recombinant Proteins and Immunotherapeutics 367
12.1 Introduction to immunotherapeutics 367
12.2 Historical background of immunotherapeutics 368
12.3 Basis of immunotherapeutics 368
12.4 Types of immunotherapeutics 369
12.5 Humanisation of antibody therapy 372
12.6 Immunotherapeutics in clinical practice 376
12.7 Advantages and disadvantages of immunotherapy 378
12.8 The future 379
12.9 Summary 380 References 380 Glossary 381 Index 403
1.1 Introduction to molecular pharmacology 1
1.2 Scope of this textbook 2
1.3 The nature of drug targets 3
1.4 Future drug targets 7
1.5 Molecular pharmacology and drug discovery 11 References 12 2 Molecular Cloning of Drug Targets 13
2.1 Introduction to molecular cloning - from DNA to drug discovery 13
2.2 ''Traditional'' pharmacology 14
2.3 The relevance of recombinant DNA technology to pharmacology/drug discovery 14
2.4 The ''cloning'' of drug targets 15
2.5 What information can DNA cloning provide? 20
2.6 Comparing the pharmacologic profile of the ''cloned'' and the ''native'' drug target 23
2.7 Reverse pharmacology illustrated on orphan GPCRs 24
2.8 Summary 27 References 27 3 G Protein-coupled Receptors 31
3.1 Introduction to G protein-coupled receptors 31
3.2 Heterotrimeric G-proteins 36
3.3 Signal transduction pathways 40
3.4 Desensitisation and down-regulation of GPCR signalling 44
3.5 Constitutive GPCR activity 45
3.6 Promiscuous G-protein coupling 47
3.7 Agonist-directed signalling 48
3.8 Allosteric modulators of GPCR function 49
3.9 Pharmacological chaperones for GPCRs 50
3.10 GPCR dimerisation 51
3.11 GPCR splice variants 63
3.12 Summary 67 References 67 Useful Web sites 70 4 Ion Channels 71
4.1 Introduction 71
4.2 Voltage-gated ion channels 73
4.3 Other types of voltage-gated ion channels 89
4.4 Ligand-gated ion channels 109
4.5 Summary 125 References 125 5 Transporter Proteins 129
5.1 Introduction 129
5.2 Classification 129
5.3 Structural analysis of transporters 132
5.4 Transporter families of pharmacological interest 133
5.5 Transporters and cellular homeostasis 167
5.6 Summary 169 References 169 6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease 175
6.1 Introduction 175
6.2 Cystic fibrosis transmembrane conductance regulator 179
6.3 Mutations in CFTR 183
6.4 Why is cystic fibrosis so common? 184
6.5 Animal models of Cystic fibrosis 186
6.6 Pharmacotherapy 186
6.7 Gene therapy 191
6.8 Conclusion 195 References 196 7 Pharmacogenomics 201
7.1 Types of genetic variation in the human genome 201
7.2 Thiopurine S-methyltransferase and K+ channel polymorphisms 202
7.3 Polymorphisms affecting drug metabolism 204
7.4 Methods for detecting genetic polymorphisms 209
7.5 Genetic variation in drug transporters 211
7.6 Genetic variation in G protein coupled receptors 215
7.7 Summary 225 References 225 Useful Web sites 226 8 Transcription Factors and Gene Expression 227
8.1 Control of gene expression 227
8.2 Transcription factors 229
8.3 CREB 233
8.4 Nuclear receptors 238
8.5 Peroxisome proliferator-activated receptors 240
8.6 Growth factors 247
8.7 Alternative splicing 247
8.8 RNA editing 251
8.9 The importance of non-coding RNAs in gene expression 257
8.10 Summary 270 References 271 9 Cellular Calcium 277
9.1 Introduction 277
9.2 Measurement of calcium 278
9.3 The exocrine pancreas 289
9.4 Calcium signalling in pancreatic acinar cells 292
9.5 Nuclear calcium signalling 303
9.6 Conclusions 310 References 311 10 Genetic Engineering of Mice 315
10.1 Introduction to genetic engineering 315
10.2 Genomics and the accumulation of sequence data 315
10.3 The mouse as a model organism 318
10.4 Techniques for genetic engineering 319
10.5 Examples of genetically-engineered mice 332
10.6 Summary 334 References 334 11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts 339
11.1 Introduction to cell signalling complexes 339
11.2 Introduction to GPCR interacting proteins 340
11.3 Methods used to identify GPCR interacting proteins 340
11.4 Functional roles of GPCR interacting proteins 345
11.5 GPCR signalling complexes 348
11.6 GPCR and ion channel complexes 355
11.7 Ion channel signalling complexes 356
11.8 Development of pharmaceuticals that target GPCR interacting proteins 356
11.9 Development of pharmaceuticals that target protein-protein interactions 356
11.10 Lipid rafts 357
11.11 Receptor-mediated endocytosis 361
11.12 Summary 364 References 364 12 Recombinant Proteins and Immunotherapeutics 367
12.1 Introduction to immunotherapeutics 367
12.2 Historical background of immunotherapeutics 368
12.3 Basis of immunotherapeutics 368
12.4 Types of immunotherapeutics 369
12.5 Humanisation of antibody therapy 372
12.6 Immunotherapeutics in clinical practice 376
12.7 Advantages and disadvantages of immunotherapy 378
12.8 The future 379
12.9 Summary 380 References 380 Glossary 381 Index 403
De oplyste priser er inkl. moms
Butikker og åbningstid
Handler du som firma
Forretningsbetingelser
Porto og forsendelse
Data & cookiepolitik
Handler du som firma
Forretningsbetingelser
Porto og forsendelse
Data & cookiepolitik
Polyteknisk Boghandel og Forlag A/S - Anker Engelundsvej 1 - 2800 Lyngby
Tlf 77 42 43 44 - email poly@polyteknisk.dk - CVR 34072655 - Sydbank Reg: 6748 Konto 0001107927
Tlf 77 42 43 44 - email poly@polyteknisk.dk - CVR 34072655 - Sydbank Reg: 6748 Konto 0001107927