Polyteknisk Boghandel

This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. 

Written by expert scientists from both academia and leading biotechnical companies, the authors provide a compelling update on current status of RNA interference with emphasis on fascinating topics including: oligonucleotides, antisense oligonucleotides; ribozymes, siRNAs, decoy oligonucleotides and aptamers. This exceptional work will be a valid resource for researchers and students as well as academics, consultants and scientists. 

Chapter 1: The Role of Backbone Modifications in Oligonucleotide-Based Strategies;

Chapter 2: Genasense (G3139): An Antisense Bcl-2 Oligodeoxyribonucleotide with Substantial Clinical Activity and a Complex Mechanism of Action;

Chapter 3: Antisense Morpholino Oligomers and Their Peptide Conjugates;

Chapter 4: Peptide-PNA Conjugates for Modulation of Gene Expression;

Chapter 5: Locked Nucleic Acid: Properties & Therapeutic Aspects;

Chapter 6: Immune Stimulatory Oligonucleotides;

Chapter 7: Decoy Oligonucleotides to Treat Inflammatory Diseases;

Chapter 8: AS1411: Development of an Anticancer Aptamer;

Chapter 9: Spielgelmer NOX-E36 for Renal Diseases;

Chapter 10: Strategies for the Delivery of Oligonucleotides In Vivo;

Chapter 11: Lipid-Mediated in vivo Delivery of Small Interfering RNAs;

Chapter 12: Vector-Mediated and Viral Delivery of Short Hairpin RNAs;

Chapter 13: Development of an RNAi Based Gene Therapy against HIV-1;

Chapter 14: RNA Based Therapies for Treatment of HIV Infection