Polyteknisk Boghandel

This book provides a perspective of nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies. Topics covered range from x-ray crystallographic studies of transition metal ion coordination by the nucleotide bases to the application of polyelectrolyte theory for understanding the nature of delocalized counterions that surround nucleic acids in solution.

Separate chapters cover how nucleic acid-metal ions play a role in the kinetics and thermodynamics of RNA folding, as well as the role of metal ions in RNA catalysis, in disease and in medicine.

The book will serve as a reference source for researchers in nucleic acids biophysics and molecular biology, but it also includes enough background material for students and researchers who have not previously worked in the field.

Nucleic acids interactions with Group I and II cations
Coordinative Bond Formation Between Metal Ions and Nucleic Acid Bases
Sequence-specific DNA-cation interactions
Metal ion coordination in G-quadruplexes
Characterization of nucleic acid metal ion binding by spectroscopic techniques
Metal ions and the thermodynamics of RNA folding
Metal ions and RNA folding kinetics
Metal ions in RNA catalysis
Polyanion models of nucleic acid-metal ion interactions
Metal ion-nucleic acid interactions in disease and medicine