Polyteknisk Boghandel

The study of protein folding and aggregation has recently acquired a high level of technical and conceptual sophistication, in which theory, computer simulations and experiments are starting to be employed in tight combination.

This book includes chapters, in all the areas, that have witnessed the major developments. Written by top experts it is unique in its comprehensive scope and coverage of all new developments in this area.

The reader will obtain a perspective of the problems faced in protein folding and aggregation, and how these problems are being solved with a multidisciplinary approach using theory, experiment, and computer simulations.

Preface: Classical Themes and Novel Approaches in Protein Folding and Aggregation;


Chapter 1: The Helix as the Simplest Protein Folding Model; Helix-Coil Theory, Stability and Design;

Chapter 2: Kinetics and Mechanisms of -Helix Formation;

Chapter 3: Protein Folding Theory; The Folding Energy Landscape: A Primer;

Chapter 4: Hydrogen Exchange Experiments; Detection and Characterization of Folding Intermediates;

Chapter 5: Statistical Differential Scanning Calorimetry; Probing Protein Folding-Unfolding Ensembles;

Chapter 6: Fast Protein Folding;

Chapter 7: Single Molecule Spectroscopy in Protein Folding; From Ensembles to Single Molecules;

Chapter 8: Computer Simulations of Protein Folding;

Chapter 9: Protein Design; Tailoring Sequence, Structure and Folding Properties;

Chapter 10: Protein Misfolding and -Amyloid Formation;

Chapter 11: Computational Studies of Protein Aggregation; Molecular Dynamics Simulations and Bioinformatic Analysis of Scenarios for Protein Aggregation