This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings.
Topics covered include, the role of ions and hydration in protein-nucleic acid interactions , transcription factors and combinatorial specificity, indirect readout of DNA sequence, single-stranded nucleic acid binding proteins, nucleic acid junctions and proteins, RNA protein recognition, and recognition of DNA damage.
It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.
Chapter 1: Introduction;
Chapter 2: The role of water and effects of small ions in site-specific protein-DNA interactions;
Chapter 3: Structural Basis for Sequence-Specific DNA Recognition by Transcription Factors and their Complexes;
Chapter 4: Indirect Readout Of DNA Sequence by Proteins;
Chapter 5: Single-stranded Nucleic Acid (SSNA)-binding Proteins;
Chapter 6: DNA junctions and their interaction with resolving enzymes;
Chapter 7: RNA-protein Interactions in Ribonucleoprotein Particles and Ribonucleases;
Chapter 8: Bending and compaction of DNA by proteins;
Chapter 9: Mode of Action of Proteins with RNA Chaperone Activity;
Chapter 10: Structure and Function of DNA Topoisomerases;
Chapter 11: DNA Transposases;
Chapter 12: Site-Specific Recombinases;
Chapter 13: DNA Nucleases;
Chapter 14: RNA-modifying enzymes