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List of Contributors XVII Preface XXV
Part I Analytical Methods and Strategies in Metallomics 1 1 The Position of Metallomics Within Other Omics Fields 3 Dirk Schaumlöffel
1.1 Introduction 3
1.2 Metallome and Metallomics in Relation to Other "-Ome" and "-Omics" Fields 3
1.3 Is Metallomics Feasible as a Global Study of the Metallome 7
1.4 Approaching the Metallome: Study of Metallome Subgroups 8
1.5 Analytical Strategies in Metallomics 8
1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals 10
1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup 11
1.8 Concluding Remarks 14 References 15 2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques 17 Daniel Pröfrock
2.1 Introduction 17
2.2 Analytical Techniques for Metallomics 19
2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation 30
2.4 Overview about Coupling Techniques 48
2.5 Final Remarks and Outlook 58 References 58 3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis 69 Heidi G. Infante
3.1 Introduction 69
3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation 70
3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species 72 References 81 4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF 83 Dirk Schaumlöffel, Robert Hutchinson, Julien Malherbe, Philippe Le Coustumer, Etienne Gontier, and Marie-Pierre Isaure
4.1 Introduction 83
4.2 Bioimaging by LA-ICP-MS 84
4.3 Bioimaging by NanoSIMS 90
4.4 Bioimaging by TEM/X-EDS 93
4.5 Bioimaging by SXRF 104
4.6 Conclusions and Outlook 108 References 109 5 Electrochemistry Coupled toMass Spectrometry for Investigating Oxidative Metabolism of Pt-Based Drug Conjugates: A Novel Approach 117 Günther Weber
5.1 Introduction 117
5.2 EC-MS Methodology 119
5.3 EC-MS of Thiols 119
5.4 Influence of Cisplatin on Thiol Oxidation 121
5.5 Conclusions 125 References 126
Part II Metallomics in Environment and Nutrition 129 6 Selenium and Selenium Species 131
6.1 Speciation Analysis Especially of Tin and Selenium in Environmental Matrices 131 Maria Ochsenkühn-Petropoulou and Fotios Tsopelas References 143
6.2 Selenium Species Extraction and Speciation in Plants and Yeast 151 Lena Ruzik, Katarzyna Bier³a, and Joanna Szpunar References 169 7 Arsenic and As Species 173
7.1 Arsenic Species in Marine Food 173 María Carmen Barciela-Alonso and Pilar Bermejo-Barrera References 198
7.2 Compounds with As-S Bonds: Analytical and Biogeochemical Reasons Why These Species have been Elusive in Biota and Environment 202 Jörg Feldmann, Andrea Raab, Helle R. Hansen, Katharina Bluemlein, and Dirk Wallschläger References 218
7.3 Arsenolipids: An overview of current analytical aspects 222 Michael Stiboller, Ronald A. Glabonjat, Georg Raber, Kenneth B. Jensen, and Kevin A. Francesconi References 234 8 Analytical Procedures for Speciation of Chromium, Aluminum, and Tin in Environmental and Biological Samples 237 Radmila Mil'cîc, Tea Zuliani, Janja Vidmar, and Janez Scancar
8.1 Speciation of Chromium 237
8.2 Speciation of Aluminum 250
8.3 Speciation of Tin 260 References 275 9 Mercury Toxicity and Speciation Analysis 285 Eva M. Krupp, Zuzana Gajdosechova, Tanja Schwerdtle, and Hanna Lohren
9.1 Mercury Toxicity 285
9.2 Mercury Speciation Analysis 291 References 298 10 Environmental Speciation of Platinum Emissions from Chemotherapy 305 Marianna Vitkova, Gunda Koellensperger, and Stephan Hann
10.1 Introduction 305
10.2 Elemental Analysis of Platinum 306
10.3 Quantification Strategies 309
10.4 Preparation of Samples for Total Platinum Analysis by ICP-MS 309
10.5 Analysis of Platinum 310
10.6 Speciation of Platinum Emissions from Chemotherapy 311
10.7 Speciation Strategies for the Determination of CPC 312
10.8 Selected Applications 312
10.9 Conclusion 314 References 315 11 Nanoparticles in Environment and Health Effect 319 Gaëtane Lespes
11.1 Introduction 319
11.2 Nanoparticle Overview 319
11.3 Analytical Strategies 326
11.4 Conclusion 334 References 335
Part III Metallomics in Medicine and Biology 339 12 Metalloproteins 341 Maria Montes-Bayón and Elisa Blanco-González
12.1 General Introduction to Metalloprotein Analysis 341
12.2 Sample Preparation Methodologies to Preserve Metal-Protein Interactions 342
12.3 Analytical Strategies for Identification of Metalloproteins 344
12.4 Quantitative Strategies for the Analysis of Metalloproteins 349 References 355 13 Biomedical and Pharmaceutical Applications 359
13.1 Selenium and Selenoproteins in Human Health and Diseases 359 Jordan Sonet, Anne-Laure Bulteau, and Laurent Chavatte Acknowledgments 370 References 370
13.2 Metal Species as Biomarkers for Medical Diagnosis: A Case Study of Alzheimer''s Disease 375 Tamara García-Barrera, José Luis Gómez-Ariza, and Belén Callejón-Leblic References 385
13.3 Vanadium Speciation as a Means in Drug Development and Monitoring for Diabetes 388 Volker Nischwitz References 398
13.4 Analysis of Pt- and Ru-Based Anticancer Drugs: New Developments 401 Sarah Theiner, Luis Galvez, Gunda Koellensperger, and Bernhard K. Keppler References 416
13.5 Silver Distribution in Skin duringWound Healing 420 Marco Roman and Carlo Barbante References 436
13.6 Neurodegeneration with Focus on Manganese and Iron Speciation 442 Katharina Neth, Julia Bornhorst, and Bernhard Michalke References 457 Index 463