The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.
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The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.
Overview of Second- and Third-Order Nonlinear Optical Processes for Deep Imaging Sangeeta Murugkar and Robert W. Boyd Complex Light Beams Enrique J. Galvez Gaussian Beam Optical Parameters in Multi-Photon Excitation Fluorescence Imaging Lingyan Shi, Adri?n Rodr?guez-Contreras, and Robert R. Alfano The Optics of Deep Optical Imaging in Tissues Using Long Wavelengths Steven L. Jacques Light Propagation and Interaction in Highly Scattering Media for Deep Tissue Imaging W. B. Wang, Lingyan Shi, Luyao Lu, Laura A. Sordillo, L. Wang, S. K. Gayen, and R. R. Alfano Application of Nonlinear Microscopy in Life Sciences Zdenek Svindrych and Ammasi Periasamy Smart Biomarker-Coated PbS Quantum Dots for Deeper Near-Infrared Fluorescence Imaging in the Second Optical Window Takashi Jin, Akira Sasaki, and Yukio Imamura Biomedical Applications in Probing Deep Tissue Using Mid-Infrared Supercontinuum Optical Biopsy Angela B. Seddon Light Propagation in Turbid Tissue-Like Scattering Media Alexander Bykov, Alexander Doronin, and Igor Meglinski Overview of the Cumulant Solution to Light Propagation Inside a Turbid Medium and Its Applications in Deep Imaging Beyond the Diffusion Approximation Min Xu, Cai Wei, and Robert R. Alfano Deep Imaging of Prostate Cancer Using Diffusion Reconstruction of Banana Paths with Near Infrared Prostatoscope Analyzer Yang Pu, Wubao Wang, Min Xu, James A. Eastham, and Robert R. Alfano Terahertz Propagation in Tissues and Its Thickness Limitation Burcu Karagoz and Hakan Altan Detection of Brain Tumors Using Stimulated Raman Scattering Microscopy Spencer Lewis and Daniel Orringer Chemical and Molecular Imaging of Deep Tissue through Photoacoustic Detection of Chemical Bond Vibrations Yingchun Cao and Ji-Xin Cheng Deep Tissue Imaging: Acoustic and Thermal Wave Propagation and Light Interactions in Tissue Idan Steinberg, Asaf Shoval, Michal Balberg, Adi Sheinfeld, Michal Tepper, and Israel Gannot Using the Transmission Matrix to Image Disordered Media Matthieu Davy, Sylvain Gigan, and Azriel Z. Genack