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List of Contributors xiii Foreword xix Preface xxi About the Companion Website xxiii Section 1 Basic Science 1 1 Introduction 3 Somesh Gupta and Nanja van Geel 2 Melanocyte and Melanogenesis: Applied Anatomy and Physiology 9 Reinhart Speeckaert and Nanja van Geel 3 Epidemiology of Vitiligo 15 Nader Aboul Fettouh and Amit G. Pandya 4 Pathogenesis of Vitiligo 19 John E. Harris 5 Understanding the Mechanisms of Repigmentation in Vitiligo 27 Ravinder Kumar, Davinder Parsad, and Amrinder J. Kanwar Section 2 Clinical Science 33 6 Classification and Clinical Features of Vitiligo 35 Sang Ho Oh and Seung Kyung Hann 7 Outcome Measures for Vitiligo 49 Brian Clinton, Viktoria Eleftheriadou, Nanja van Geel, Laila Benzekri, Amit G. Pandya, and Khaled Ezzedine 8 Evaluation and Treatment of the Psychosocial Burden of Vitiligo 61 Vishal Gupta and M. Ramam 9 Patient Support, Education, and Compliance 69 Richard H. Huggins, Jackie Gardner, and Amit G. Pandya 10 Goals of Vitiligo Treatment, and EvidenceBased Practice Guidelines for Medical and Surgical Management 77 Kevin Prier and Amit G. Pandya 11 The Concept of Stability of Vitiligo and Stabilization Therapies 81 Anuradha Bishnoi and Davinder Parsad Section 3 Phototherapy 91 12 NarrowBand Ultraviolet B Phototherapy in Vitiligo 93 Narumol Silpa archa and Henry W. Lim 13 UVABased Phototherapy: PUVA, PUVASol, and UVA1 Phototherapy 105 Ljubomir B. Novakovic 14 Targeted Phototherapy in Vitiligo 113 Mohammed Al Jamal, James L. Griffith, Iltefat H. Hamzavi, and Henry W. Lim Section 4 Medical Management 123 15 Immunomodulators and Immunosuppressives in Vitiligo Treatment 125 Anuradha Bishnoi and Davinder Parsad 16 Topical Glucocorticoids, Topical Calcineurin Inhibitors, and Topical Vitamin D3 Analogs 133 Sai Yee Chuah and Boon Kee Goh 17 Other Therapies in Vitiligo 141 Narumol Silpa archa, James L. Griffith, Iltefat H. Hamzavi, and Pearl E. Grimes 18 Biologic Therapies for Vitiligo 151 Pablo Michel and Amit G. Pandya 19 Evidence Toward Integrated Management of Vitiligo, Combining Ayurveda and Homeopathy with Modern Dermatology 159 Saravu R. Narahari, Madhur G. Aggithaya, Kuthaje S. Bose, and Kodimoole S. Prasanna Section 5 Surgical Therapies: History, Patient Selection, and Classification 171 20 History and Chronology of Development of Surgical Therapies for Vitiligo 173 Koushik Lahiri and Abhishek De 21 Patient Selection, Pre and Postoperative Information in Surgical Therapies for Vitiligo 185 Nanja van Geel and Mats J. Olsson 22 Classification of Surgical Therapies in Vitiligo 193 James L. Griffith, Mohammed Al Jamal, and Iltefat H. Hamzavi Section 6 Surgical Therapies: Tissue Grafting 209 23 Minigrafting for Vitiligo 211 Koushik Lahiri 24 Suction Blister Epidermal Grafting 225 Savita Yadav and Somesh Gupta 25 Thin and UltraThin Skin Grafts for Vitiligo 241 Imran Majid 26 Treatment of Leukoderma by Transplantation of UltraThin Epidermal Sheets Using a Motorized Dermatome 249 Mats J. Olsson 27 Mesh Grafts for Vitiligo 257 Chakravarthi R. Srinivas and Reena Rai 28 Smash Grafting 261 Sumit Kar, Ajay Krishnan, and Sudhir Singh 29 Therapeutic Needling and Needling Micrografting 267 Khalifa E. Sharquie and Adil A. Noaimi 30 Complications and Limitations of Melanocyte Transplantation 273 Yvon Gauthier and Laila Benzekri Section 7 Surgical Therapies: Cellular Grafting 279 31 Treatment of Leukoderma by Transplantation of Basal Cell Layer Suspension 281 Mats J. Olsson 32 NonCultured Extracted Follicle Outer Root Sheath Cell Suspension Transplantation 293 Kanika Sahni and Somesh Gupta 33 LongTerm Results of NonCultured Epidermal Cellular Grafting in Vitiligo 299 Nanja van Geel, Sofie De Schepper, Hilde Lapeere, Barbara Boone, Boon Kee Goh, and Reinhart Speeckaert 34 Simplified NonCultured Cellular Grafting 303 Boon Kee Goh 35 Novel Methods of Preparing Epidermal Cell Suspension for Transplantation in Vitiligo 309 Vishal Gupta, Sanjeev Gupta, Kanika Sahni, and Somesh Gupta 36 Management of Vitiligo: Setting Up a Tissue Culture Laboratory 317 Rafal Czajkowski, Malgorzata Maj, and Tomasz Drewa 37 Treatment of Leukoderma by Transplantation of Cultured Autologous Melanocytes 323 Mats J. Olsson 38 Transplantation of InVitroCultured Epithelial Grafts for Vitiligo and Piebaldism 337 Liliana Guerra, Sergio Bondanza, and Desanka Raskovic 39 Application of Lasers for Abrasion in Transplantation Procedures for Vitiligo 351 Gwang Seong Choi 40 Cell Delivery on Recipient Skin 357 Thomas Hunziker 41 Safety Concerns in Transplantation of InVitroCultured Cellular Grafts 363 Liliana Guerra, Elena Dellambra, Patrizia Paterna, and Somesh Gupta Section 8 Special Issues in Medical and Surgical Therapies 369 42 Surgical Management of Vitiligo of Lips, Eyelids, and Genitals 371 Riti Bhatia and Somesh Gupta 43 Surgical Management of Acral Vitiligo 389 Munish Paul 44 Surgical Management of Leukotrichia 401 Amrendra Kumar 45 Surgical Treatments of Leukodermas Other Than Vitiligo Vulgaris 407 Mats J. Olsson 46 Ethnic Issues in Management of Vitiligo and Sun Protection 417 Haneol S. Jeong, Michelle Rodrigues, and Amit G. Pandya 47 Management Issues for Vitiligo in Children and Pregnant Women 427 Freya Van Driessche and Nanette Silverberg 48 Combination Treatments for Vitiligo 439 Anuradha Bishnoi and Davinder Parsad 49 Micropigmentation 451 Gurvinder P. Thami 50 Camouflage in Vitiligo 459 Chakravarthi R. Srinivas, Pradeep Balasubramanian, and C.K. Shashidharan Nair 51 Depigmentation Treatment for Vitiligo: Bleaching Cream, Laser, and Cryotherapy 469 Nanja van Geel and Monique R.T.M. Thissen 52 Future Directions in the Treatment of Vitiligo 475 Vishal Gupta and Somesh Gupta 53 Informed Consent 491 Mats J. Olsson Index 495