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Viser: An Introduction to Medicinal Chemistry
An Introduction to Medicinal Chemistry
Graham L. Patrick
(2017)
Sprog: Engelsk
Detaljer om varen
- 5. Udgave
- Paperback: 848 sider
- Udgiver: Oxford University Press (November 2017)
- ISBN: 9780199697397
The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents.
Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills.
Online Resource Centre
The Online Resource Centre features:
For registered adopters of the book:
DT Answers to end-of-chapter questions
DT Figures from the book
DT Power Point slides
DT Test Bank questions
For students:
DT Multiple Choice Questions
DT Web articles
DT Molecular Modelling Exercises
DT 3D Rotatable structures
1: StatinsPART C Drug discovery, design, and development12. Drug discovery: finding a lead13. Drug design: optimizing target interactions14. Drug design: optimizing access to the target15. Getting the drug to marketCase study
2: The design of ACE inhibitorsCase study
3: Artemisinin and related antimalarial drugsCase study 4
: The design of oxamniquinePART D Tools of the trade16. Combinatorial synthesis17. Computers in medicinal chemistry18. Quantitative structure-activity relationships (QSAR)Case study
5: De novo design of a thymidylate synthase inhibitorPART E Selected topics in medicinal chemistry19. Antibacterial agents20. Antiviral agents21. Anticancer agents22. Cholinergics, anticholinergics, and anticholinesterases23. Drugs acting on the adrenergic nervous system24. Opioid analgesics25. Antiulcer agentsCase study
6: Steroidal anti-inflammatory agentsCase Study
7: Design of a novel antidepressantAppendices
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